This product is a high-concentration, highly purified
polyphenolic blend that has been scientifically demonstrated
to make positive shifts in functional metabolic targets.
It provides multidimensional support to maintain blood
pressure levels already within the normal range, manage
weight, and increase satiety and appetite control. This
product provides a potent formula for those seeking to
optimize their metabolism and cardiovascular health.

Lemon verbena (Lippia citriodora) has been used as a food
spice, cosmetic, and in traditional formulations in South
America and Southern Europe. Hibiscus flower (Hibiscus
sabdariffa L.) is used in traditional Chinese formulations in
the manner of a tea to help maintain normal blood pressure
levels and normal inflammatory balance. Metabolaid® is a
combination of the plant polyphenols in lemon verbena and
hibiscus flower extracts. These extracts have been shown to
work synergistically on the activation of the energy sensor
AMPK and promote optimal metabolic efficiency through the
modulation of fat metabolism.

In a 2018 double-blind, placebo-controlled and randomized
trial in 56 subjects with weight management challenges,
participants were given 500 mg of a combination of
polyphenolic extracts from Lippia citriodora and Hibiscus
sabdarifa L. for two months and showed significant
improvement in body weight, abdominal circumference, and
body fat percentage. Heart rate and systolic blood pressure
also were maintained within the normal range.6

In another eight-week, randomized, double-blind, placebo-controlled
trial, 54 participants given the same extract showed an
improvement of anthropometric measurements, maintenance
of blood pressure within the normal range, and improved
heart rate. In addition, they experienced positive perception
of overall health status. This polyphenolic combination has
been shown to significantly increase metabolic function and
support healthy weight by decreasing appetite biomarkers.
This may help to avoid the undesired weight rebound typical of calorie restriction diets.5

Coffee is one of the most consumed drinks in the world. Green
coffee beans are the beans from the Coffea fruit that have not
yet been roasted. Coffee beans are naturally high in chlorogenic
acid, and roasting them reduces the chlorogenic acid content.
Chlorogenic acid, a polyphenol, is what holds the antioxidant
properties and increases the overall health benefits of coffee;7
therefore, the effects and benefits of coffee are maximized in
its natural and unroasted state. In addition, the green coffee
bean extract in this product has had the caffeine removed, so
the benefits of the polyphenols can be maximized.
A meta-analysis of nine randomized, controlled trials with
green coffee bean extract (GCBE) administered for four
weeks showed a benefit in maintaining blood pressure levels
already in the normal range—both systolic and diastolic.8
In
another systemic review and meta-analysis study consisting
of 637 participants, it was shown that green coffee bean
extract consumption can help maintain optimal lipid markers,
decrease body weight, and improve metabolism and glucose
disposal.9
Finally, in a randomized clinical trial, 43 subjects
consumed GCBE for eight weeks. After supplementation, all
indices of cardiovascular health showed benefits. Additionally,
waist circumference and appetite score of the individuals
supplemented with GCBE indicated a significant decline.10

Magnesium is a cofactor in more than 300 enzyme systems
that regulate diverse biochemical reactions in the body,
including protein synthesis, muscle and nerve function,
blood glucose control, and blood pressure regulation.11-13
Magnesium is required for energy creation, which involves
oxidative phosphorylation and glycolysis. It contributes to the
development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays
a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.13 The role of magnesium as an enzyme cofactor for activities that generate adenosine triphosphate (ATP) highlight its significance for maintaining energy levels and metabolic efficiency.

A meta-analysis of randomized, double-blind, placebo-controlled studies on the effects of magnesium supplementation on blood pressure showcased 34 trials involving 2,028 participants who, while using magnesium supplementation with a median duration of three months, showed benefits in maintaining systolic and diastolic blood pressure within the normal range for adults.14,15 Overall, oral magnesium citrate supplementation has been shown to maintain healthy blood pressure and blood sugar markers.15

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton
PK, He J. Global burden of hypertension: analysis of
worldwide data. Lancet. 2005;365(9455):217-223.
2. Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito I. Green
coffee bean extract and its metabolites have a hypotensive
effect in spontaneously hypertensive rats. Hypertens Res.
2002;25(1):99-107.
3. GBD 2019 Risk Factors Collaborators. Global burden of 87
risk factors in 204 countries and territories, 1990-2019: a
systematic analysis for the Global Burden of Disease Study
2019. Lancet. 2020;396(10258):1223-1249.
4. Gibbs J, Gaskin E, Ji C, Miller MA, Cappuccio FP. The
effect of plant-based dietary patterns on blood pressure:
a systematic review and meta-analysis of controlled
intervention trials. J Hypertens. 2021;39(1):23-37.
5. Boix-Castejón M, Herranz-López M, Gago AP, et al.
Correction: Hibiscus and lemon verbena polyphenols
modulate appetite-related biomarkers in overweight
subjects: a randomized controlled trial. Food Funct.
2018;9(7):4037.
6. Herranz-López M, Olivares-Vicente M, Boix-Castejón M,
et al. Differential effects of a combination of Hibiscus
sabdariffa and Lippia citriodora polyphenols in overweight/
obese subjects: A randomized controlled trial. Sci Rep.
2019;9(1):2999. Published 2019 Feb 28.
7. Haidari F, Samadi M, Mohammadshahi M, Jalali MT, Engali
KA. Energy restriction combined with green coffee
bean extract affects serum adipocytokines and the
body composition in obese women. Asia Pac J Clin Nutr.
2017;26(6):1048-1054.
8. Han B, Nazary-Vannani A, Talaei S, et al. The effect of
green coffee extract supplementation on blood pressure:
A systematic review and meta-analysis of randomized
controlled trials. Phytother Res. 2019;33(11):2918-2926.
9. Pourmasoumi M, Hadi A, Marx W, Najafgholizadeh A, Kaur
S, Sahebkar A. The Effect of Green Coffee Bean Extract
on Cardiovascular Risk Factors: A Systematic Review and
Meta-analysis. Adv Exp Med Biol. 2021;1328:323-345.
10. Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of
green coffee extract supplementation on anthropometric
indices, glycaemic control, blood pressure, lipid profile,
insulin resistance and appetite in patients with the
metabolic syndrome: a randomised clinical trial. Br J Nutr.2018;119(3):250-258.

11. Institute of Medicine (US) Standing Committee on the
Scientific Evaluation of Dietary Reference Intakes. Dietary
Reference Intakes for Calcium, Phosphorus, Magnesium,
Vitamin D, and Fluoride. Washington (DC): National
Academies Press (US); 1997.
12. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR,
Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia
of Dietary Supplements. 2nd ed. New York, NY: Informa
Healthcare; 2010:527-37.
13. Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ,
Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and
Disease. 11th ed. Baltimore, Mass: Lippincott Williams &
Wilkins; 2012:159-75.
14. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium
Supplementation on Blood Pressure: A Meta-Analysis
of Randomized Double-Blind Placebo-Controlled Trials.
Hypertension. 2016;68(2):324-333.
15. Afitska K, Clavel J, Kisters K, Vormann J, Werner T.
Magnesium citrate supplementation decreased blood
pressure and HbA1c in normomagnesemic subjects with
metabolic syndrome: a 12-week, placebo-controlled,
double-blinded pilot trial. Magnes Res. 2021;34(3):130-139.